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Synapse & Transmission — NEET Biology MCQs with Solutions

Free NEET Biology Synapse & Transmission MCQs with step-by-step solutions (38 questions). Part of Neural Control and Coordination. Practise online on Prepizo — no login needed.

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Questions with solutions

Q1 — Synapse & Transmission · easy · theory
The junction between two neurons across which an impulse passes is the:
A. Node of Ranvier
B. Dendron
C. Axon hillock
D. Synapse  ✓ Correct
Solution: A synapse is the junction between the axon terminal of one neuron and the dendrite of the next.
Q2 — Synapse & Transmission · easy · theory
At a chemical synapse, the impulse is transmitted by molecules called:
A. Enzymes
B. Hormones
C. Antibodies
D. Neurotransmitters  ✓ Correct
Solution: Neurotransmitters (e.g. acetylcholine) diffuse across the synaptic cleft to relay the impulse.
Q3 — Synapse & Transmission · medium · theory
The arrival of an impulse at the axon terminal causes the entry of ______, triggering neurotransmitter release:
A. K⁺ ions
B. Ca²⁺ ions  ✓ Correct
C. Cl⁻ ions
D. Mg²⁺ ions
Solution: Ca²⁺ influx at the terminal makes synaptic vesicles fuse and release neurotransmitter into the cleft.
Q4 — Synapse & Transmission · medium · theory
At an electrical synapse, impulse transmission is ______ than at a chemical synapse:
A. The same speed
B. Faster (almost instant, via direct current flow)  ✓ Correct
C. Blocked
D. Slower
Solution: Electrical synapses allow direct, very fast current flow between cells; chemical synapses are slower (with a synaptic delay).
Q5 — Synapse & Transmission · hard · theory
Neurotransmitters are released from the pre-synaptic terminal by:
A. Simple diffusion of the whole vesicle
B. Exocytosis of synaptic vesicles into the synaptic cleft  ✓ Correct
C. Active pumping of ions only
D. Endocytosis
Solution: Synaptic vesicles fuse with the pre-synaptic membrane and release neurotransmitter by exocytosis.
Q6 — Synapse & Transmission · hard · theory
The key difference between chemical and electrical synapses is that chemical synapses:
A. Use neurotransmitters and have a synaptic delay; electrical use direct ion flow with no delay  ✓ Correct
B. Are faster and use ions directly
C. Do not use any signalling
D. Only occur in muscles
Solution: Chemical synapses transmit via neurotransmitters (with a brief delay); electrical synapses conduct current directly and rapidly.
Q7 — Synapse & Transmission · easy · numerical
At a chemical synapse, the pre-synaptic and post-synaptic membranes are separated by a fluid-filled space called the:
A. Neuromuscular endplate
B. Nissl space
C. Synaptic cleft  ✓ Correct
D. Node of Ranvier
Solution: The synaptic cleft is the narrow gap between the pre-synaptic and post-synaptic membranes across which the neurotransmitter diffuses at a chemical synapse.
Q8 — Synapse & Transmission · easy · numerical
The neurotransmitter that is released at cholinergic synapses and at the neuromuscular junction is:
A. Acetylcholine  ✓ Correct
B. Gamma-aminobutyric acid (GABA)
C. Histamine
D. Glycine
Solution: Acetylcholine is the neurotransmitter released at cholinergic synapses and at the skeletal neuromuscular junction, where it binds receptors on the post-synaptic membrane.
Q9 — Synapse & Transmission · easy · numerical
Transmission across a chemical synapse is unidirectional (one-way) mainly because:
A. The post-synaptic neuron cannot generate an action potential
B. The synaptic cleft allows ions to flow only in one direction
C. Neurotransmitter is stored and released only from the pre-synaptic membrane, while receptors lie only on the post-synaptic membrane  ✓ Correct
D. Myelin on the post-synaptic side blocks the return of the impulse
Solution: Only the pre-synaptic terminal contains synaptic vesicles with neurotransmitter, and only the post-synaptic membrane bears the receptors. This asymmetry makes chemical transmission strictly one-way.
Q10 — Synapse & Transmission · easy · numerical
At an electrical synapse, the impulse passes directly from one neuron to the next because the membranes are:
A. Separated by a wide cleft filled with neurotransmitter
B. Connected only through the cerebrospinal fluid
C. In very close apposition, allowing current to flow directly like along an axon  ✓ Correct
D. Joined by a thick myelin bridge
Solution: At electrical synapses the pre- and post-synaptic membranes lie extremely close, so current (ions) flows directly between them, making transmission faster than at chemical synapses but rarer in the human body.
Q11 — Synapse & Transmission · medium · numerical
Arrange the following events of chemical synaptic transmission in the correct order: (1) neurotransmitter binds receptors on post-synaptic membrane; (2) Ca²⁺ enters the pre-synaptic terminal; (3) impulse reaches the axon terminal; (4) synaptic vesicles fuse and release neurotransmitter into the cleft.
A. 3 → 2 → 4 → 1  ✓ Correct
B. 4 → 2 → 3 → 1
C. 2 → 3 → 4 → 1
D. 3 → 4 → 2 → 1
Solution: The impulse reaches the terminal, opening Ca²⁺ channels; Ca²⁺ influx triggers vesicle fusion and neurotransmitter release into the cleft; the transmitter then binds post-synaptic receptors. Order: 3 → 2 → 4 → 1.
Q12 — Synapse & Transmission · medium · numerical
Assertion (A): The influx of Ca²⁺ into the axon terminal is essential for neurotransmitter release. Reason (R): Ca²⁺ promotes the fusion of synaptic vesicles with the pre-synaptic membrane, causing exocytosis of the transmitter.
A. A is false but R is true
B. Both A and R are true and R is the correct explanation of A  ✓ Correct
C. A is true but R is false
D. Both A and R are true but R is not the correct explanation of A
Solution: Arrival of the impulse opens voltage-gated Ca²⁺ channels; Ca²⁺ entry causes synaptic vesicles to fuse with the membrane and release transmitter by exocytosis. R correctly explains why Ca²⁺ influx is needed for release.
Q13 — Synapse & Transmission · medium · numerical
Binding of an excitatory neurotransmitter to receptors on the post-synaptic membrane most directly causes:
A. Synthesis of new vesicles in the post-synaptic cell
B. Opening of ion channels that depolarise the post-synaptic membrane  ✓ Correct
C. Immediate reuptake of the transmitter into the pre-synaptic terminal
D. Closure of all Na⁺ channels on the post-synaptic membrane
Solution: When an excitatory transmitter binds its receptor, ligand-gated ion channels open and produce a depolarising (excitatory post-synaptic) potential that may generate a new impulse in the post-synaptic neuron.
Q14 — Synapse & Transmission · medium · numerical
Which of the following statements comparing electrical and chemical synapses is INCORRECT?
A. Electrical synapses are relatively rare in the human nervous system
B. Transmission at electrical synapses is almost always faster than at chemical synapses
C. Chemical synapses use neurotransmitter molecules to relay the signal
D. Chemical synapses transmit impulses faster than electrical synapses  ✓ Correct
Solution: Transmission across an electrical synapse is faster than across a chemical synapse because of the synaptic delay introduced by transmitter release and diffusion at chemical synapses. So saying chemical synapses are faster is incorrect.
Q15 — Synapse & Transmission · medium · numerical
The brief delay (synaptic delay) that occurs during transmission across a chemical synapse but not at an electrical synapse is due to the time taken for:
A. Regeneration of the resting potential in the axon
B. Release, diffusion across the cleft, and receptor binding of the neurotransmitter  ✓ Correct
C. Active transport of the impulse across the wide cleft
D. The myelin to depolarise between the two neurons
Solution: At a chemical synapse the transmitter must be released, diffuse across the cleft, and bind post-synaptic receptors, all of which take time and cause the synaptic delay. Electrical synapses transmit current directly and have essentially no delay.
Q16 — Synapse & Transmission · medium · numerical
After acetylcholine has acted on the post-synaptic membrane at a cholinergic synapse, continuous stimulation is prevented because the transmitter is:
A. Pumped unchanged back into the post-synaptic neuron
B. Permanently locked to the receptor for many minutes
C. Rapidly broken down by the enzyme acetylcholinesterase in the cleft  ✓ Correct
D. Converted into a second excitatory neurotransmitter
Solution: Acetylcholinesterase hydrolyses acetylcholine in the synaptic cleft, ending its action so the post-synaptic membrane can return to rest. Without this breakdown the receptor would be continuously stimulated.
Q17 — Synapse & Transmission · medium
Fill in the blanks. I. A nerve impulse is ...(a)... from one neuron to another through junctions called ...(b).... II. ...(c)... of an impulse across electrical synapses is very similar to impulse ...(d)... along a single axon.
A. a-Conducted, b-Tight junction, c-Conduction, d-Transmission
B. a-Transmitted, b-Synapses, c-Transmission, d-Conduction  ✓ Correct
C. a-Transmitted, b-Adhering junction, c-Transmission, d-Conduction
D. a-Conducted, b-neuro-muscular junction, c-Conduction, d-Transmission
Solution: A nerve impulse is transmitted from one neuron to another through junctions called synapses; transmission across electrical synapses is very similar to impulse conduction along a single axon.
Q18 — Synapse & Transmission · easy
Synapses are of
A. Two types-Chemical and mechanical
B. Two types-Pre synaptic and post synaptic
C. Three types-Electric, chemical and mechanical
D. Two types-Electrical and chemical  ✓ Correct
Solution: Synapses are of two types: electrical synapses and chemical synapses.
Q19 — Synapse & Transmission · medium
Read the following statements and find out the incorrect statements. a. A synapse is formed by the membranes of a pre-synaptic neuron and a post-synaptic neuron, which may or may not be separated by a gap called synaptic cleft. b. At electrical synapses, the membranes of pre- and post-synaptic neurons are in very close proximity. c. Electrical current can flow directly from one neuron into the other across chemical synapses. d. Impulse transmission across a chemical synapse is always faster than that across a electric synapse. e. Electrical synapses are rare in our system.
A. d and e
B. c and d  ✓ Correct
C. a and b
D. b and c
Solution: Electrical current flows across electrical (not chemical) synapses, and chemical synapse transmission is slower than electrical; so statements c and d are incorrect.
Q20 — Synapse & Transmission · easy
During transmission of nerve impulse, the released neurotransmitter binds to their specific receptors, present on the
A. Both (1) and (2)
B. Pre-synaptic membrane
C. Synaptic vesicles
D. Post-synaptic membrane  ✓ Correct
Solution: The neurotransmitter binds to specific receptors present on the post-synaptic membrane.
Q21 — Synapse & Transmission · easy
The binding of the neurotransmitter with the receptors opens ion channels allowing the entry of ions which can generate a new potential in the
A. Post-synaptic membrane  ✓ Correct
B. Synaptic vesicles
C. Pre-synaptic membrane
D. Synaptic cleft
Solution: The entry of ions through opened channels generates a new potential in the post-synaptic neuron's membrane.
Q22 — Synapse & Transmission · easy
The new potential developed in the post-synaptic neuron is
A. Either excitatory or inhibitory  ✓ Correct
B. Excitatory only
C. Inhibitory only
D. Neither excitatory nor inhibitory
Solution: The new potential developed in the post-synaptic neuron may be either excitatory or inhibitory.
Q23 — Synapse & Transmission · easy
Joint between axon of a neuron and dendrite of next is called
A. Synapse  ✓ Correct
B. Junction
C. Bridge
D. Cleft
Solution: The junction between the axon of one neuron and the dendrite of the next is called a synapse.
Q24 — Synapse & Transmission · easy
Synaptic vesicle occurs in
A. Presynaptic neuron  ✓ Correct
B. Synaptic cleft
C. Post-synaptic neuron
D. None of the above
Solution: Synaptic vesicles containing neurotransmitters are present in the axon terminal of the presynaptic neuron.
Q25 — Synapse & Transmission · easy
Neurotransmitters are stored in
A. Myelin sheath
B. Cell body
C. Dendrites
D. Synaptic vesicles  ✓ Correct
Solution: Neurotransmitters are stored in synaptic vesicles within the axon terminal.
Q26 — Synapse & Transmission · easy
A nerve impulse is transmitted from one neuron to another through junctions called
A. Node of Ranvier
B. Tight junction
C. Synapses  ✓ Correct
D. Neuro-muscular junction
Solution: A nerve impulse is transmitted from one neuron to another through junctions called synapses.
Q27 — Synapse & Transmission · easy
At a chemical synapse, the membranes of the pre- and post-synaptic neurons are separated by a fluid-filled space called
A. Synaptic vesicle
B. Synaptic cleft  ✓ Correct
C. Synovial cavity
D. Synaptic knob
Solution: At a chemical synapse, the pre- and post-synaptic membranes are separated by a fluid-filled space called the synaptic cleft.
Q28 — Synapse & Transmission · easy
Chemicals that are involved in the transmission of impulses at chemical synapses, are called
A. Both (2) and (3)
B. Hormones
C. Neurotransmitters  ✓ Correct
D. Growth regulators
Solution: At chemical synapses, impulse transmission is mediated by chemicals called neurotransmitters (e.g., acetylcholine).
Q29 — Synapse & Transmission · easy
When an impulse arrives at the axon terminal, it stimulates the movement of the
A. Synaptic cleft
B. Synaptic knob
C. Both (2) and (3)
D. Synaptic vesicles  ✓ Correct
Solution: The arriving impulse causes synaptic vesicles (containing neurotransmitter) to move towards and fuse with the pre-synaptic membrane.
Q30 — Synapse & Transmission · medium
Read the following statements and choose the correct option.
A. The new potential developed in pre-synaptic neuron will always be inhibitory.
B. The new potential developed in post-synaptic neuron will always be excitatory.
C. Impulse transmission across an electrical synapse is always faster than that across a chemical synapse.  ✓ Correct
D. All of the above
Solution: Electrical synapse transmission is always faster than chemical synapse transmission; the new post-synaptic potential may be excitatory or inhibitory.